Comparative Study of Intravenous Infusion of Clonidine And/or Magnesium Sulphate on Haemodynamic Stress Response to Tracheal Intubation and Pneumoperitoneum during Laproscopic Surgery

Introduction: Laryngotracheal intubation and co2 pneumoperitoneum in laproscopic surgery is associated with significant stress response. In this prospective, randomized study, we investigated the efficacy of magnesium sulfate and clonidine to prevent adverse hemodynamic stress response. Methodology: 60 patients of either sex (18-60yrs) undergoing elective laproscopy surgery were randomly divided in two groups. 1. In Goup C, IV infusion of Inj clonidine 1.5 μg/ kg while in group M, Inj magnesium sulphate 50mg/kg diluted in 100ml NS over 15 min was started 30 min before surgery and intraoperatively, IV infusion of clonidine 1μg /kg/hr and magnesium sulphate 10mg/kg/hr was started respectively before creation of pneumoperitoneum. Results: Mean heart rate was significantly high immediately after intubation in group M compared to group c and significantly less in clonidine group before and immediately after pneumoperitoneum. No significant difference was observed in mean blood pressure in both groups. Time for rescue analgesic was prolonged in group M. Sedation, extubation time and discharge time was significantly longer in group M. Conclusion: Administration of clonidine and magnesium sulfate produces hemodynamic stability during intubation and pneumoperitoneum in laproscopic surgery.